Researchers at the University of Chicago Medical Centre have discovered a novel way to help treat Type-2 diabetes. The research group discovered that CRISPR gene-editing therapy, administered through skin grafts, could help treat Type-2 diabetes and obesity.
A paper describing the work was published n the medical journal Cell Stem Cell. According to the paper, genetically modifying glucagon-like peptide 1(GLP1), a hormone which stimulates the pancreas to secrete insulin, the researchers were able to both decrease appetite and regulate blood sugar levels in mice. This work suggests that treatments for diabetics like insulin shots could be replaced by simple skin grafts one day.
This would be quite a significant advance. The procedure of applying the skin grafts is safe, minimally invasive, inexpensive, and easy to monitor. Also, the patient is not required t administer their own ongoing treatment.
Int his study,two groups of mice were fed a high-fat diet. One group had the skin grafts, while the other did not. The mice which had undergone the gene therapy gained only half as much weight as those which had not. Also, this group of mice developed less resistance to insulin. Note that resistance to insulin can be a symptom which commonly precedes Type-2 diabetes.
Here’s a quote from Xiaoyang Wu, an assistant professor at the University of Chicago, on the sublect:
“Skin transplant is easy to make with cultured skin stem cells, and has been used clinically for treatment of burn wounds for decades. In this study, we took advantage of this well established platform and showed that skin transplant with engineered skin stem cells can be used to deliver therapeutic proteins for treatment of obesity and diabetes. In animal models, we have shown that this technology can reduce body weight gain and inhibit Type-2 diabetes development.”
This is certainly a useful discovery. Hopefully, with this and other diabetes-related projects, we are getting closer to finding a more permanent way to improve lives for millions of people worldwide who suffer from diabetes.